24. Chain-like assembly of gold nanoparticles on artificial DNA templates via ‘click chemistry’

We present a new type of azide-functionalized gold nanoparticle and their coupling to an alkyne-modified DNA duplex using the copper(I)-catalyzed Huisgen cycloaddition (‘click chemistry’), resulting in a chain-like assembly of nanoparticles on the DNA template.

This work is featured in Chemical Science Magazine, 2008 (http://www.rsc.org/Publishing/ChemScience/Volume/2008/02/DNA_nanowires.asp)